Tilekbek Zhoroev

Applied Mathematician & Data Scientist

I develop probabilistic models for clinical decision support and demand forecasting, with a focus on quantifying prediction uncertainty.

Tilekbek Zhoroev

Affiliations

Microsoft NC State University SAS Institute Johnson & Johnson PeriGen

About Me

I'm a Data Scientist at Microsoft with a Ph.D. in Applied Mathematics from North Carolina State University. My research centers on probabilistic machine learning and uncertainty quantification, particularly in settings where predictions directly influence decisions.

During my Ph.D., I developed Gaussian process models for predicting labor progression in real time and used physics-informed neural networks to recover hidden infection dynamics in kidney transplant patients. I also worked on Alzheimer's cognitive decline forecasting at Johnson & Johnson, hotel demand prediction at SAS, and Bayesian uncertainty quantification funded by the NSF.

Uncertainty Quantification Physics-Informed Neural Networks Gaussian Processes Bayesian Inference Clinical Decision Support Fractional Calculus

Tools & Skills

Python TensorFlow GPflow PyTorch MATLAB NumPy/SciPy Git LaTeX SQL
Gaussian Processes
Physics-Informed ML
Clinical Decision Support
Uncertainty Quantification

Research

PeriGen / NIH / NICHD

Labor Progression Prediction

We developed a Gaussian process model that learns each patient's unique labor pattern in real time and achieved statistically significant sensitivity improvements over WHO and ACOG guidelines on a dataset of 49,694 births.

Read more
NC State University (PhD)

Hidden Dynamics in BK Virus Infection

After kidney transplant, BK virus reactivation can cause graft loss, but the mechanism linking viral dynamics to kidney function is poorly understood. We combined PINNs with symbolic regression to recover interpretable ODE terms from sparse clinical data.

Read more
Johnson & Johnson

Alzheimer's Disease Progression

Most Alzheimer's models predict only the total ADAS-Cog score. We used GP models with ordinal likelihood on CPAD clinical trial data to forecast all 11 individual subscores, capturing how different cognitive domains decline at different rates.

Read more
SAS Institute (IDeaS)

Demand Forecasting & Event Detection

We built hierarchical GP models for hotel room demand forecasting and a DMD-based anomaly detection pipeline for identifying demand-driving events, tested across major hotel chains at IDeaS.

Read more
NC State University · NSF

Uncertainty Quantification

We developed Bayesian methods for detecting when model-data mismatch reflects structural model error versus parameter uncertainty, with simultaneous prediction intervals for extrapolation.

Read more
Western Kentucky University

Fractional Pharmacokinetics

We extended classical PK/PD models with nabla fractional operators to capture memory effects in tumor growth and anti-cancer drug response.

Read more

Publications

Loading publications...

Experience

Data Scientist

Microsoft May 2025 - Present

Redmond, WA

  • Developing ML models for operational analytics within Microsoft (role started May 2025)

R&D Intern

SAS Institute (IDeaS) Jan 2024 - May 2025

Cary, NC

  • Built Sparse Hierarchical Gaussian Process models for hotel room demand forecasting, benchmarked against IDeaS' production system across Accor, Choice, and Wyndham hotel chains
  • Designed meta-learning pipelines so new hotels with limited booking history could still get reliable forecasts from day one
  • Developed a multi-stage special event detection system combining Dynamic Mode Decomposition, statistical anomaly detection, and GP classification to identify demand-driving events from occupancy patterns

Data Science Researcher

PeriGen Jun 2022 - Aug 2024 (Part-time, concurrent with PhD)

Cary, NC

  • Developed a Sparse Gaussian Process model that predicts patient-specific labor progression curves in real time, producing calibrated uncertainty bands for each patient.
  • Validated on 49,694 births from the Consortium on Safe Labor; achieved statistically significant sensitivity improvement over WHO and ACOG guidelines
  • Optimized training with stochastic variational inference for a 10x speedup, making real-time bedside prediction practical
  • Co-authored two journal publications with NIH/NICHD researchers and OB-GYN clinicians

Data Science Intern

Johnson & Johnson May 2023 - Aug 2023

Titusville, NJ

  • Built a Variational Gaussian Process model with ordinal likelihood to predict the longitudinal progression of all 11 ADAS-Cog subscores, the gold-standard cognitive endpoint in Alzheimer's clinical trials
  • Worked with patient-level data from the CPAD database (1,683 patients across 36 clinical trials)
  • Compared five GP configurations using 5-fold cross-validation; results showed that ordinal likelihood handles the discrete, ordered nature of cognitive scores better than continuous alternatives

Research & Teaching Assistant

North Carolina State University Aug 2020 - May 2025

Raleigh, NC

  • Developed a Physics-Informed Neural Network framework to model hidden BK virus infection dynamics in kidney transplant patients, recovering interpretable ODE terms through symbolic regression
  • Built a Bayesian method for simultaneous interval prediction under NSF funding, addressing uncertainty propagation and model-data discrepancy detection in physical and biological systems
  • Taught six undergraduate mathematics courses (Calculus I-III, Linear Algebra, Differential Equations, Statistics)

Education

NC State Aug 2020 - May 2025

Ph.D. in Applied Mathematics

North Carolina State University

GPA: 4.00/4.00

Dissertation: Developing Gaussian Process and Theory-Informed Neural Network Models for Clinical Decision Making

Advisor: Dr. Kevin Flores

WKU Aug 2018 - May 2020

M.S. in Mathematics

Western Kentucky University

GPA: 4.00/4.00 | Outstanding Graduate Student

Thesis: Controllability and Observability of Linear Nabla Discrete Fractional Systems

Erciyes Sep 2014 - Jun 2017

B.S. in Mathematics

Erciyes University, Turkey

GPA: 4.00/4.00 | First Place, Science College

Teaching

Courses taught as Teaching Assistant at North Carolina State University (Aug 2020 – May 2025)

MA 141 – Calculus I

MA 241 – Calculus II

MA 242 – Calculus III

MA 305 – Linear Algebra

MA 341 – Differential Equations

ST 311 – Statistics

Honors and Awards

Siewert Graduate Fellowship

NC State University, 2020-2022

Outstanding Graduate Student

Western Kentucky University, 2020

Fruit of the Loom Mathematics Award

Western Kentucky University, 2019

Honorable Mention, 55th IMO

International Mathematical Olympiad, Cape Town, 2014

Silver Medal, National Olympiad

Kyrgyzstan Mathematical Olympiad, 2013

Graduated First in Class, College of Science

Erciyes University, Science College, 2017

Contact

Interested in collaborating on research or have a question? Let's connect.